1.3M XNAS Volume
XNAS 18 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 44.65 per share. | 17 Mar 2025 | 25,000 | 339,181 (0%) | 0% | 44.7 | 1,116,250 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 44.38 per share. | 17 Mar 2025 | 12,648 | 326,533 (0%) | 0% | 44.4 | 561,318 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 44.38 per share. | 17 Mar 2025 | 4,389 | 101,005 (0%) | 0% | 44.4 | 194,784 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 17 Mar 2025 | 20,900 | 58,563 (0%) | 0% | 23.3 | 486,134 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 44.38 per share. | 17 Mar 2025 | 2,775 | 34,888 (0%) | 0% | 44.4 | 123,155 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2025 | 20,900 | 129,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 45.14 per share. | 17 Mar 2025 | 20,900 | 37,663 (0%) | 0% | 45.1 | 943,426 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2025 | 100 | 149,900 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 14 Mar 2025 | 100 | 37,663 (0%) | 0% | 45 | 4,500 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.26 per share. | 14 Mar 2025 | 100 | 37,763 (0%) | 0% | 23.3 | 2,326 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 116,096 | 480,277 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 176,547 | 176,547 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 2,254 | 2,254 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 2,293 | 2,293 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 58,465 | 58,465 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 39,450 | 144,844 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 47,593 | 47,593 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 2,749 | 2,749 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 32,687 | 70,350 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 43.62 per share. | 13 Mar 2025 | 26,771 | 37,663 (0%) | 0% | 43.6 | 1,167,751 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 43.44 per share. | 06 Mar 2025 | 16,970 | 364,181 (0%) | 0% | 43.4 | 737,177 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 43.27 per share. | 06 Mar 2025 | 8,228 | 105,394 (0%) | 0% | 43.3 | 356,026 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 43.27 per share. | 06 Mar 2025 | 3,341 | 64,434 (0%) | 0% | 43.3 | 144,565 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 43.23 per share. | 05 Mar 2025 | 25,000 | 381,151 (0%) | 0% | 43.2 | 1,080,750 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2025 | 2,000 | 31,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 42.50 per share. | 04 Mar 2025 | 2,000 | 116,071 (0%) | 0% | 42.5 | 85,000 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 04 Mar 2025 | 2,000 | 118,071 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 42.50 per share. | 04 Mar 2025 | 900 | 15,108 (0%) | 0% | 42.5 | 38,250 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.88 per share. | 03 Mar 2025 | 8,743 | 406,151 (0%) | 0% | 42.9 | 374,900 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 42.88 per share. | 03 Mar 2025 | 2,449 | 113,622 (0%) | 0% | 42.9 | 105,013 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 42.88 per share. | 03 Mar 2025 | 1,114 | 67,775 (0%) | 0% | 42.9 | 47,768 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 18 Feb 2025 | 2,000 | 118,071 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 45.98 per share. | 18 Feb 2025 | 2,000 | 116,071 (0%) | 0% | 46.0 | 91,960 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 2,000 | 33,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert E. Landry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 25,538 | 25,538 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 04 Feb 2025 | 2,000 | 118,071 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2025 | 2,000 | 35,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 48.06 per share. | 04 Feb 2025 | 2,000 | 116,071 (0%) | 0% | 48.1 | 96,120 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.60 per share. | 21 Jan 2025 | 2,000 | 118,071 (0%) | 0% | 10.6 | 21,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jan 2025 | 2,000 | 37,105 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 45.92 per share. | 21 Jan 2025 | 2,000 | 116,071 (0%) | 0% | 45.9 | 91,840 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 434 | 48,987 (0%) | 0% | 48.9 | 21,236 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 127 | 23,115 (0%) | 0% | 48.9 | 6,214 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 127 | 24,686 (0%) | 0% | 48.9 | 6,214 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 255 | 25,637 (0%) | 0% | 48.9 | 12,477 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 48.93 per share. | 02 Jan 2025 | 255 | 16,008 (0%) | 0% | 48.9 | 12,477 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 16 Dec 2024 | 742 | 25,301 (0%) | 0% | 7.4 | 5,469 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2024 | 742 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 48.61 per share. | 16 Dec 2024 | 742 | 24,559 (0%) | 0% | 48.6 | 36,069 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 11 Dec 2024 | 1,780 | 40,241 (0%) | 0% | 7.4 | 13,119 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2024 | 1,780 | 10,092 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 11 Dec 2024 | 10,092 | 48,553 (0%) | 0% | 7.4 | 74,378 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2024 | 10,092 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 11 Dec 2024 | 1,780 | 38,461 (0%) | 0% | 50.4 | 89,748 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 10 Dec 2024 | 5,300 | 123,371 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 5,300 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 50.65 per share. | 10 Dec 2024 | 2,000 | 116,071 (0%) | 0% | 50.7 | 101,300 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 50.63 per share. | 10 Dec 2024 | 5,300 | 118,071 (0%) | 0% | 50.6 | 268,339 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 11,529 | 409,207 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 11,530 | 414,894 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 5,843 | 403,364 (0%) | 0% | 51.5 | 300,973 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 4,000 | 118,071 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 2,028 | 114,071 (0%) | 0% | 51.5 | 104,462 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 4,000 | 116,099 (0%) | 0% | 0 | Common Stock | |
| Robert C. Wong | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 273 | 17,889 (0%) | 0% | 51.5 | 14,062 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 766 | 18,655 (0%) | 0% | 0 | Common Stock | |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 764 | 18,162 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 1,536 | 37,451 (0%) | 0% | 51.5 | 79,119 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 4,303 | 38,987 (0%) | 0% | 0 | Common Stock | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 4,304 | 41,755 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.51 per share. | 03 Dec 2024 | 1,351 | 65,712 (0%) | 0% | 51.5 | 69,590 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 3,177 | 68,889 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Dec 2024 | 3,176 | 67,063 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.76 per share. | 02 Dec 2024 | 5,000 | 397,678 (0%) | 0% | 50.8 | 253,800 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2024 | 5,000 | 54,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 02 Dec 2024 | 5,000 | 402,678 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 50.17 per share. | 26 Nov 2024 | 5,300 | 113,878 (0%) | 0% | 50.2 | 265,901 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Nov 2024 | 5,300 | 5,300 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 50.14 per share. | 26 Nov 2024 | 2,000 | 111,878 (0%) | 0% | 50.1 | 100,280 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 26 Nov 2024 | 5,300 | 119,178 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 25 Nov 2024 | 742 | 24,559 (0%) | 0% | 50 | 37,100 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2024 | 742 | 742 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 25 Nov 2024 | 742 | 25,301 (0%) | 0% | 7.4 | 5,469 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 18 Nov 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2024 | 5,000 | 59,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.55 per share. | 18 Nov 2024 | 5,000 | 397,456 (0%) | 0% | 50.6 | 252,750 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Nov 2024 | 5,300 | 10,600 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 58.48 per share. | 12 Nov 2024 | 5,300 | 114,920 (0%) | 0% | 58.5 | 309,944 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 58.48 per share. | 12 Nov 2024 | 1,042 | 113,878 (0%) | 0% | 58.5 | 60,936 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 12 Nov 2024 | 5,300 | 120,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 01 Nov 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 5,000 | 64,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 51.63 per share. | 01 Nov 2024 | 5,000 | 397,456 (0%) | 0% | 51.6 | 258,150 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 51.90 per share. | 30 Oct 2024 | 5,300 | 116,920 (0%) | 0% | 51.9 | 275,070 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 5,300 | 15,900 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 51.93 per share. | 30 Oct 2024 | 2,000 | 114,920 (0%) | 0% | 51.9 | 103,860 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 30 Oct 2024 | 5,300 | 122,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 52.25 per share. | 28 Oct 2024 | 4,452 | 24,559 (0%) | 0% | 52.3 | 232,617 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Oct 2024 | 4,452 | 1,484 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.37 per share. | 28 Oct 2024 | 4,452 | 29,011 (0%) | 0% | 7.4 | 32,811 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 54.18 per share. | 15 Oct 2024 | 5,300 | 118,920 (0%) | 0% | 54.2 | 287,154 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2024 | 5,300 | 21,200 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 54.20 per share. | 15 Oct 2024 | 2,000 | 116,920 (0%) | 0% | 54.2 | 108,400 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 15 Oct 2024 | 5,300 | 124,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 09 Oct 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Oct 2024 | 5,000 | 69,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.61 per share. | 09 Oct 2024 | 5,000 | 397,456 (0%) | 0% | 55.6 | 278,050 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 5,300 | 26,500 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 52.09 per share. | 01 Oct 2024 | 5,300 | 118,920 (0%) | 0% | 52.1 | 276,077 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 01 Oct 2024 | 5,300 | 124,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 52.11 per share. | 01 Oct 2024 | 2,000 | 118,920 (0%) | 0% | 52.1 | 104,220 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 403 | 38,461 (0%) | 0% | 52.6 | 21,198 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 118 | 22,988 (0%) | 0% | 52.6 | 6,207 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 118 | 24,559 (0%) | 0% | 52.6 | 6,207 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 237 | 25,382 (0%) | 0% | 52.6 | 12,466 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 52.60 per share. | 01 Oct 2024 | 237 | 15,753 (0%) | 0% | 52.6 | 12,466 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 30 Sep 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2024 | 5,000 | 74,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.14 per share. | 30 Sep 2024 | 5,000 | 397,456 (0%) | 0% | 52.1 | 260,700 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2024 | 5,300 | 31,800 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.76 per share. | 17 Sep 2024 | 2,000 | 120,920 (0%) | 0% | 56.8 | 113,520 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.77 per share. | 17 Sep 2024 | 5,300 | 122,920 (0%) | 0% | 56.8 | 300,881 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 17 Sep 2024 | 5,300 | 128,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 16 Sep 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.99 per share. | 16 Sep 2024 | 5,000 | 397,456 (0%) | 0% | 56.0 | 279,950 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2024 | 5,000 | 79,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.61 per share. | 09 Sep 2024 | 5,000 | 25,600 (0%) | 0% | 21.6 | 108,050 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2024 | 5,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 54.92 per share. | 09 Sep 2024 | 5,000 | 20,600 (0%) | 0% | 54.9 | 274,600 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 03 Sep 2024 | 5,000 | 402,456 (0%) | 0% | 6.7 | 33,350 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 5,000 | 84,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 57.03 per share. | 03 Sep 2024 | 5,000 | 397,456 (0%) | 0% | 57.0 | 285,150 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 5,300 | 37,100 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 57.02 per share. | 03 Sep 2024 | 5,300 | 122,920 (0%) | 0% | 57.0 | 302,206 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.99 per share. | 03 Sep 2024 | 2,084 | 122,920 (0%) | 0% | 57.0 | 118,767 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 03 Sep 2024 | 5,300 | 128,220 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Brett A. Pletcher | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Aug 2024 | 51,039 | 51,039 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Brett A. Pletcher | EVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Aug 2024 | 33,140 | 33,140 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.61 per share. | 26 Aug 2024 | 5,000 | 25,600 (0%) | 0% | 21.6 | 108,050 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 5,000 | 5,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 57.26 per share. | 26 Aug 2024 | 5,000 | 20,600 (0%) | 0% | 57.3 | 286,300 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 20 Aug 2024 | 5,300 | 130,304 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 5,300 | 42,400 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.26 per share. | 20 Aug 2024 | 5,300 | 125,004 (0%) | 0% | 56.3 | 298,178 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 56.23 per share. | 20 Aug 2024 | 2,000 | 125,004 (0%) | 0% | 56.2 | 112,460 | Common Stock |
| Robert I. Blum | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Aug 2024 | 1,956 | 397,456 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 55.20 per share. | 12 Aug 2024 | 5,000 | 20,600 (0%) | 0% | 55.2 | 276,000 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.61 per share. | 12 Aug 2024 | 5,000 | 25,600 (0%) | 0% | 21.6 | 108,050 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 5,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 12 Aug 2024 | 11,500 | 410,912 (0%) | 0% | 6.7 | 76,705 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.17 per share. | 12 Aug 2024 | 11,500 | 399,412 (0%) | 0% | 55.2 | 634,455 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 11,500 | 89,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 06 Aug 2024 | 5,300 | 127,004 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2024 | 5,300 | 47,700 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.70 per share. | 06 Aug 2024 | 5,300 | 123,704 (0%) | 0% | 53.7 | 284,610 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.74 per share. | 06 Aug 2024 | 2,000 | 121,704 (0%) | 0% | 53.7 | 107,480 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 59.49 per share. | 30 Jul 2024 | 11,500 | 399,412 (0%) | 0% | 59.5 | 684,135 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 30 Jul 2024 | 11,500 | 410,912 (0%) | 0% | 6.7 | 76,705 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 11,500 | 101,227 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 59.84 per share. | 29 Jul 2024 | 5,000 | 20,600 (0%) | 0% | 59.8 | 299,200 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jul 2024 | 5,000 | 15,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.61 per share. | 29 Jul 2024 | 5,000 | 25,600 (0%) | 0% | 21.6 | 108,050 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 23 Jul 2024 | 5,300 | 134,304 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2024 | 5,300 | 53,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 57.02 per share. | 23 Jul 2024 | 5,300 | 129,004 (0%) | 0% | 57.0 | 302,206 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 57.02 per share. | 23 Jul 2024 | 2,000 | 129,004 (0%) | 0% | 57.0 | 114,040 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 55.82 per share. | 15 Jul 2024 | 5,000 | 20,600 (0%) | 0% | 55.8 | 279,100 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.68 per share. | 15 Jul 2024 | 5,000 | 25,600 (0%) | 0% | 10.7 | 53,400 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 5,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 10 Jul 2024 | 5,767 | 410,912 (0%) | 0% | 6.7 | 38,466 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2024 | 5,767 | 112,727 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 54.29 per share. | 10 Jul 2024 | 11,500 | 399,412 (0%) | 0% | 54.3 | 624,335 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2024 | 5,300 | 58,300 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 55.89 per share. | 09 Jul 2024 | 2,000 | 131,004 (0%) | 0% | 55.9 | 111,780 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 55.91 per share. | 09 Jul 2024 | 5,300 | 133,004 (0%) | 0% | 55.9 | 296,323 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 09 Jul 2024 | 5,300 | 138,304 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 54.61 per share. | 05 Jul 2024 | 253 | 15,516 (0%) | 0% | 54.6 | 13,816 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 5,000 | 5,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 54.22 per share. | 01 Jul 2024 | 5,000 | 20,600 (0%) | 0% | 54.2 | 271,100 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.68 per share. | 01 Jul 2024 | 5,000 | 25,600 (0%) | 0% | 10.7 | 53,400 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 54.05 per share. | 01 Jul 2024 | 11,500 | 405,145 (0%) | 0% | 54.1 | 621,575 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 388 | 38,058 (0%) | 0% | 0 | Common Stock | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 114 | 22,870 (0%) | 0% | 0 | Common Stock | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 114 | 24,441 (0%) | 0% | 0 | Common Stock | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 228 | 25,145 (0%) | 0% | 0 | Common Stock | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 228 | 15,769 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 25 Jun 2024 | 5,300 | 138,304 (0%) | 0% | 8.0 | 42,188 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.71 per share. | 25 Jun 2024 | 5,300 | 133,004 (0%) | 0% | 53.7 | 284,663 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2024 | 5,300 | 63,600 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.74 per share. | 25 Jun 2024 | 2,000 | 133,004 (0%) | 0% | 53.7 | 107,480 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.68 per share. | 17 Jun 2024 | 5,000 | 25,600 (0%) | 0% | 10.7 | 53,400 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2024 | 5,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 52.55 per share. | 17 Jun 2024 | 5,000 | 20,600 (0%) | 0% | 52.6 | 262,750 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.60 per share. | 17 Jun 2024 | 11,551 | 427,594 (0%) | 0% | 52.6 | 607,583 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.59 per share. | 17 Jun 2024 | 10,949 | 416,645 (0%) | 0% | 52.6 | 575,808 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jun 2024 | 5,422 | 68,900 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.03 per share. | 11 Jun 2024 | 2,366 | 135,004 (0%) | 0% | 53.0 | 125,469 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 53.05 per share. | 11 Jun 2024 | 5,422 | 137,370 (0%) | 0% | 53.0 | 287,637 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 11 Jun 2024 | 5,422 | 142,792 (0%) | 0% | 8.0 | 43,159 | Common Stock |
| Muna Bhanji | Director | Sale of securities on an exchange or to another person at price $ 52.07 per share. | 10 Jun 2024 | 2,000 | 17,631 (0%) | 0% | 52.1 | 104,140 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 48.85 per share. | 04 Jun 2024 | 22,500 | 439,145 (0%) | 0% | 48.9 | 1,099,125 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 48.88 per share. | 03 Jun 2024 | 13,011 | 16,653 (0%) | 0% | 48.9 | 635,978 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 5,000 | 15,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 48.64 per share. | 03 Jun 2024 | 5,000 | 15,600 (0%) | 0% | 48.6 | 243,200 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.68 per share. | 03 Jun 2024 | 5,000 | 20,600 (0%) | 0% | 10.7 | 53,400 | Common Stock |
| Robert A. Harrington | Director | Sale of securities on an exchange or to another person at price $ 48.64 per share. | 03 Jun 2024 | 1,580 | 15,541 (0%) | 0% | 48.6 | 76,851 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 53,417 | 53,417 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 34,684 | 34,684 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 20,600 (0%) | 0% | 0 | Common Stock | |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 37,670 (0%) | 0% | 0 | Common Stock | |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 22,756 (0%) | 0% | 0 | Common Stock | |
| Santo J. Costa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Santo J. Costa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 20,600 (0%) | 0% | 0 | Common Stock | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 24,327 (0%) | 0% | 0 | Common Stock | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 24,917 (0%) | 0% | 0 | Common Stock | |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 19,631 (0%) | 0% | 0 | Common Stock | |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 5,600 | 17,121 (0%) | 0% | 0 | Common Stock | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2024 | 3,636 | 3,636 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 65.11 per share. | 07 May 2024 | 14,186 | 138,417 (0%) | 0% | 65.1 | 923,650 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 65.11 per share. | 07 May 2024 | 1,361 | 137,056 (0%) | 0% | 65.1 | 88,615 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 May 2024 | 14,186 | 0 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 07 May 2024 | 14,186 | 152,603 (0%) | 0% | 6.7 | 94,621 | Common Stock |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 64.54 per share. | 25 Apr 2024 | 10,562 | 32,070 (0%) | 0% | 64.5 | 681,671 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Apr 2024 | 150 | 138,417 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 74.31 per share. | 09 Apr 2024 | 28,605 | 142,567 (0%) | 0% | 74.3 | 2,125,638 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 09 Apr 2024 | 28,605 | 171,172 (0%) | 0% | 6.7 | 190,795 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Apr 2024 | 28,605 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 74.32 per share. | 09 Apr 2024 | 4,000 | 138,567 (0%) | 0% | 74.3 | 297,280 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 61,490 | 461,221 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 69,464 | 69,464 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 1,568 | 1,568 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 23,103 | 23,103 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 1,541 | 1,541 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 21,333 | 142,567 (0%) | 0% | 0 | Common Stock | |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 1,403 | 1,403 | - | - | Incentive Stock Option (Right to Buy) | |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 4,079 | 29,664 (0%) | 0% | 0 | Common Stock | |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 3,308 | 3,308 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 1,224 | 1,224 | - | - | Incentive Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 16,941 | 63,887 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2024 | 18,346 | 18,346 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 05 Mar 2024 | 28,604 | 167,577 (0%) | 0% | 6.7 | 190,789 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 67.53 per share. | 05 Mar 2024 | 4,000 | 138,973 (0%) | 0% | 67.5 | 270,120 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2024 | 28,604 | 28,605 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 67.56 per share. | 05 Mar 2024 | 28,604 | 138,973 (0%) | 0% | 67.6 | 1,932,486 | Common Stock |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 67.68 per share. | 04 Mar 2024 | 25,341 | 416,456 (0%) | 0% | 67.7 | 1,715,079 | Common Stock |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.88 per share. | 04 Mar 2024 | 16,725 | 399,731 (0%) | 0% | 66.9 | 1,118,568 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.88 per share. | 04 Mar 2024 | 8,109 | 121,234 (0%) | 0% | 66.9 | 542,330 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 67.68 per share. | 04 Mar 2024 | 9,630 | 133,343 (0%) | 0% | 67.7 | 651,758 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.88 per share. | 04 Mar 2024 | 857 | 25,585 (0%) | 0% | 66.9 | 57,316 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 67.68 per share. | 04 Mar 2024 | 1,783 | 26,442 (0%) | 0% | 67.7 | 120,673 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 67.68 per share. | 04 Mar 2024 | 2,202 | 52,049 (0%) | 0% | 67.7 | 149,031 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.88 per share. | 04 Mar 2024 | 5,103 | 46,946 (0%) | 0% | 66.9 | 341,289 | Common Stock |
| John Henderson T. | Director | Sale of securities on an exchange or to another person at price $ 76.48 per share. | 14 Feb 2024 | 5,000 | 42,632 (0%) | 0% | 76.5 | 382,400 | Common Stock |
| T. Henderson John | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.44 per share. | 14 Feb 2024 | 5,000 | 47,632 (0%) | 0% | 4.4 | 22,200 | Common Stock |
| Henderson T. John | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2024 | 5,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert Blum I. | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 76.85 per share. | 13 Feb 2024 | 12,500 | 441,797 (0%) | 0% | 76.9 | 960,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Feb 2024 | 12,500 | 118,494 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Blum I. Robert | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 13 Feb 2024 | 12,500 | 454,297 (0%) | 0% | 6.7 | 83,375 | Common Stock |
| Malik Ibraham Fady | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 06 Feb 2024 | 28,605 | 175,578 (0%) | 0% | 6.7 | 190,795 | Common Stock |
| Ibraham Fady Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2024 | 28,605 | 57,209 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Ibraham Malik Fady | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 79.28 per share. | 06 Feb 2024 | 4,000 | 142,973 (0%) | 0% | 79.3 | 317,120 | Common Stock |
| Fady Malik Ibraham | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 79.30 per share. | 06 Feb 2024 | 28,605 | 146,973 (0%) | 0% | 79.3 | 2,268,377 | Common Stock |
| Blum Robert I. | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 79.57 per share. | 31 Jan 2024 | 12,500 | 441,797 (0%) | 0% | 79.6 | 994,625 | Common Stock |
| I. Blum Robert | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2024 | 12,500 | 130,994 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| I. Blum Robert | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 31 Jan 2024 | 12,500 | 454,297 (0%) | 0% | 6.7 | 83,375 | Common Stock |
| Blum I. Robert | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 19 Jan 2024 | 12,500 | 454,297 (0%) | 0% | 6.7 | 83,375 | Common Stock |
| I. Robert Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 81.42 per share. | 19 Jan 2024 | 12,500 | 441,797 (0%) | 0% | 81.4 | 1,017,750 | Common Stock |
| I. Blum Robert | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jan 2024 | 12,500 | 143,494 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John Henderson T. | Director | Sale of securities on an exchange or to another person at price $ 85.14 per share. | 12 Jan 2024 | 5,000 | 42,632 (0%) | 0% | 85.1 | 425,700 | Common Stock |
| Henderson T. John | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2024 | 5,000 | 5,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John Henderson T. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.44 per share. | 12 Jan 2024 | 5,000 | 47,632 (0%) | 0% | 4.4 | 22,200 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2024 | 11,678 | 0 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Malik Ibraham | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 86.98 per share. | 04 Jan 2024 | 11,678 | 150,973 (0%) | 0% | 87.0 | 1,015,752 | Common Stock |
| Fady Malik Ibraham | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 86.99 per share. | 04 Jan 2024 | 4,000 | 146,973 (0%) | 0% | 87.0 | 347,960 | Common Stock |
| Ibraham Malik Fady | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 04 Jan 2024 | 11,678 | 162,651 (0%) | 0% | 8.0 | 92,957 | Common Stock |
| Robert Blum I. | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 02 Jan 2024 | 12,500 | 454,297 (0%) | 0% | 6.7 | 83,375 | Common Stock |
| Smith Sandford Drexel | Director | Grant, award, or other acquisition of securities at price $ 84.12 per share. | 02 Jan 2024 | 148 | 18,801 (0%) | 0% | 84.1 | 12,450 | Common Stock |
| Robert Harrington A. | Director | Grant, award, or other acquisition of securities at price $ 84.12 per share. | 02 Jan 2024 | 148 | 11,521 (0%) | 0% | 84.1 | 12,450 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 84.12 per share. | 02 Jan 2024 | 148 | 19,317 (0%) | 0% | 84.1 | 12,450 | Common Stock |
| Blum Robert I. | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 12,500 | 155,994 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell Wierenga D. | Director | Grant, award, or other acquisition of securities at price $ 84.12 per share. | 02 Jan 2024 | 74 | 18,727 (0%) | 0% | 84.1 | 6,225 | Common Stock |
| Nancy Wysenski J. | Director | Grant, award, or other acquisition of securities at price $ 84.12 per share. | 02 Jan 2024 | 74 | 17,156 (0%) | 0% | 84.1 | 6,225 | Common Stock |
| Henderson John T. | Director | Grant, award, or other acquisition of securities at price $ 84.12 per share. | 02 Jan 2024 | 252 | 42,632 (0%) | 0% | 84.1 | 21,198 | Common Stock |
| I. Robert Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 85.08 per share. | 02 Jan 2024 | 12,500 | 441,797 (0%) | 0% | 85.1 | 1,063,500 | Common Stock |
| Wierenga Wendell D. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2023 | 5,000 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wierenga D. Wendell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.44 per share. | 27 Dec 2023 | 5,000 | 23,653 (0%) | 0% | 4.4 | 22,200 | Common Stock |
| D. Wierenga Wendell | Director | Sale of securities on an exchange or to another person at price $ 73.60 per share. | 27 Dec 2023 | 5,000 | 18,653 (0%) | 0% | 73.6 | 368,000 | Common Stock |
| D. Wierenga Wendell | Director | Sale of securities on an exchange or to another person at price $ 73.60 per share. | 27 Dec 2023 | 5,000 | 18,653 (0%) | 0% | 73.6 | 368,000 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2023 | 5,000 | 5,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wierenga D. Wendell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.44 per share. | 27 Dec 2023 | 5,000 | 23,653 (0%) | 0% | 4.4 | 22,200 | Common Stock |
| Blum I. Robert | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 18 Dec 2023 | 12,500 | 454,297 (0%) | 0% | 6.7 | 83,375 | Common Stock |
| Robert Blum I. | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2023 | 12,500 | 168,494 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John Henderson T. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2023 | 13,020 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Blum I. Robert | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 36.95 per share. | 18 Dec 2023 | 12,500 | 441,797 (0%) | 0% | 37.0 | 461,875 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.72 per share. | 18 Dec 2023 | 13,020 | 44,838 (0%) | 0% | 6.7 | 87,494 | Common Stock |
| T. John Henderson | Director | Sale of securities on an exchange or to another person at price $ 36.34 per share. | 18 Dec 2023 | 2,458 | 42,380 (0%) | 0% | 36.3 | 89,324 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Aug 2023 | 10,000 | 0 | - | - | Incentive Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Aug 2023 | 2,500 | 255,994 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 33.99 per share. | 25 Aug 2023 | 12,500 | 441,417 (0%) | 0% | 34.0 | 424,875 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 25 Aug 2023 | 10,000 | 453,917 (0%) | 0% | 8.0 | 79,600 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.67 per share. | 25 Aug 2023 | 2,500 | 443,917 (0%) | 0% | 6.7 | 16,675 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.72 per share. | 21 Aug 2023 | 6,020 | 24,225 (0%) | 0% | 6.7 | 40,454 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2023 | 6,020 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 32.02 per share. | 21 Aug 2023 | 6,020 | 18,205 (0%) | 0% | 32.0 | 192,760 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 31.70 per share. | 10 Aug 2023 | 2,500 | 158,164 (0%) | 0% | 31.7 | 79,250 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2023 | 1,809 | 11,708 | - | - | Incentive Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2023 | 10,691 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.63 per share. | 01 Aug 2023 | 1,809 | 441,417 (0%) | 0% | 32.6 | 59,025 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 01 Aug 2023 | 1,809 | 443,226 (0%) | 0% | 9.7 | 17,457 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.63 per share. | 01 Aug 2023 | 10,691 | 441,417 (0%) | 0% | 32.6 | 348,831 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 01 Aug 2023 | 10,691 | 452,108 (0%) | 0% | 9.6 | 103,168 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 13 Jul 2023 | 12,500 | 453,917 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jul 2023 | 12,500 | 20,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 35.28 per share. | 13 Jul 2023 | 12,500 | 441,417 (0%) | 0% | 35.3 | 440,940 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 35.37 per share. | 13 Jul 2023 | 2,500 | 160,664 (0%) | 0% | 35.4 | 88,425 | Common Stock |
| Muna Bhanji | Director | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 07 Jul 2023 | 2,000 | 14,031 (0%) | 0% | 34.1 | 68,235 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 33.36 per share. | 03 Jul 2023 | 636 | 31,056 (0%) | 0% | 33.4 | 21,217 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 33.36 per share. | 03 Jul 2023 | 187 | 16,858 (0%) | 0% | 33.4 | 6,238 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2023 | 12,500 | 33,191 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.60 per share. | 03 Jul 2023 | 12,500 | 441,417 (0%) | 0% | 32.6 | 407,500 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 03 Jul 2023 | 12,500 | 453,917 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 33.36 per share. | 03 Jul 2023 | 374 | 18,205 (0%) | 0% | 33.4 | 12,477 | Common Stock |
| Sandford Drexel Smith | Director | Grant, award, or other acquisition of securities at price $ 33.36 per share. | 03 Jul 2023 | 374 | 18,205 (0%) | 0% | 33.4 | 12,477 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 33.36 per share. | 03 Jul 2023 | 374 | 18,721 (0%) | 0% | 33.4 | 12,477 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 33.36 per share. | 03 Jul 2023 | 374 | 10,925 (0%) | 0% | 33.4 | 12,477 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 12 Jun 2023 | 12,500 | 453,917 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 37.06 per share. | 12 Jun 2023 | 12,500 | 441,417 (0%) | 0% | 37.1 | 463,250 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2023 | 12,500 | 45,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 38.07 per share. | 08 Jun 2023 | 2,500 | 163,164 (0%) | 0% | 38.1 | 95,175 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2023 | 12,500 | 58,191 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 37.67 per share. | 31 May 2023 | 12,500 | 441,058 (0%) | 0% | 37.7 | 470,875 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 31 May 2023 | 12,500 | 453,558 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 37.41 per share. | 16 May 2023 | 12,500 | 441,058 (0%) | 0% | 37.4 | 467,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2023 | 12,500 | 70,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 16 May 2023 | 12,500 | 453,558 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.78 per share. | 15 May 2023 | 4,166 | 29,586 (0%) | 0% | 6.8 | 28,245 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2023 | 4,166 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 37.77 per share. | 15 May 2023 | 4,166 | 25,420 (0%) | 0% | 37.8 | 157,350 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 39.50 per share. | 11 May 2023 | 1,787 | 165,396 (0%) | 0% | 39.5 | 70,587 | Common Stock |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 30,420 (0%) | 0% | 0 | Common Stock | |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 16,671 (0%) | 0% | 0 | Common Stock | |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Santo J. Costa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| Santo J. Costa | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 17,831 (0%) | 0% | 0 | Common Stock | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Sandford Drexel Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Sandford Drexel Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 17,831 (0%) | 0% | 0 | Common Stock | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 18,347 (0%) | 0% | 0 | Common Stock | |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 16,031 (0%) | 0% | 0 | Common Stock | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 10,000 | 10,000 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2023 | 5,000 | 10,551 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 03 May 2023 | 7,000 | 174,183 (0%) | 0% | 8.0 | 55,720 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 03 May 2023 | 7,000 | 167,183 (0%) | 0% | 40 | 280,000 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2023 | 7,000 | 74,322 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 37.68 per share. | 28 Apr 2023 | 12,500 | 441,058 (0%) | 0% | 37.7 | 471,000 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 28 Apr 2023 | 12,500 | 453,558 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Apr 2023 | 12,500 | 83,191 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 14 Apr 2023 | 12,500 | 453,558 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 35.61 per share. | 14 Apr 2023 | 12,500 | 441,058 (0%) | 0% | 35.6 | 445,125 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Apr 2023 | 12,500 | 95,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 34.21 per share. | 13 Apr 2023 | 4,000 | 167,183 (0%) | 0% | 34.2 | 136,840 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 37.71 per share. | 03 Apr 2023 | 530 | 25,420 (0%) | 0% | 37.7 | 19,986 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 37.71 per share. | 03 Apr 2023 | 149 | 11,671 (0%) | 0% | 37.7 | 5,619 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 37.71 per share. | 03 Apr 2023 | 298 | 12,831 (0%) | 0% | 37.7 | 11,238 | Common Stock |
| Sandford Drexel Smith | Director | Grant, award, or other acquisition of securities at price $ 37.71 per share. | 03 Apr 2023 | 298 | 12,831 (0%) | 0% | 37.7 | 11,238 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 37.71 per share. | 03 Apr 2023 | 298 | 13,347 (0%) | 0% | 37.7 | 11,238 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 37.71 per share. | 03 Apr 2023 | 298 | 5,551 (0%) | 0% | 37.7 | 11,238 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Mar 2023 | 12,500 | 108,191 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 35.05 per share. | 28 Mar 2023 | 12,500 | 441,058 (0%) | 0% | 35.1 | 438,125 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 28 Mar 2023 | 12,500 | 453,558 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 12,500 | 120,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 37.26 per share. | 15 Mar 2023 | 12,500 | 441,058 (0%) | 0% | 37.3 | 465,750 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 15 Mar 2023 | 12,500 | 453,558 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 39.10 per share. | 09 Mar 2023 | 4,000 | 171,183 (0%) | 0% | 39.1 | 156,400 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 82,500 | 441,058 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 12,500 | 133,191 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.13 per share. | 06 Mar 2023 | 11,900 | 358,558 (0%) | 0% | 39.1 | 465,647 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 39.94 per share. | 06 Mar 2023 | 12,500 | 370,458 (0%) | 0% | 39.9 | 499,250 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 06 Mar 2023 | 12,500 | 382,958 (0%) | 0% | 9.7 | 120,625 | Common Stock |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 162,445 | 162,445 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 2,555 | 2,555 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 77,445 | 77,445 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.13 per share. | 06 Mar 2023 | 4,958 | 135,183 (0%) | 0% | 39.1 | 194,007 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 40,000 | 175,183 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 2,555 | 2,555 | - | - | Incentive Stock Option (Right to Buy) | |
| Ching W. Jaw | SVP Finance & CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.13 per share. | 06 Mar 2023 | 2,403 | 57,346 (0%) | 0% | 39.1 | 94,029 | Common Stock |
| Ching W. Jaw | SVP Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 47,445 | 47,445 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Ching W. Jaw | SVP Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 2,555 | 2,555 | - | - | Incentive Stock Option (Right to Buy) | |
| Ching W. Jaw | SVP Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 30,000 | 87,346 (0%) | 0% | 0 | Common Stock | |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 9,536 | 9,536 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 2,464 | 2,464 | - | - | Incentive Stock Option (Right to Buy) | |
| Robert C. Wong | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 6,000 | 27,613 (0%) | 0% | 0 | Common Stock | |
| Robert C. Wong | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.13 per share. | 06 Mar 2023 | 692 | 21,613 (0%) | 0% | 39.1 | 27,078 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 30,000 | 53,683 (0%) | 0% | 0 | Common Stock | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 47,445 | 47,445 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Andrew M. Callos | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 2,555 | 2,555 | - | - | Incentive Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.60 per share. | 02 Mar 2023 | 32,724 | 370,458 (0%) | 0% | 39.6 | 1,295,870 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.60 per share. | 02 Mar 2023 | 10,785 | 140,141 (0%) | 0% | 39.6 | 427,086 | Common Stock |
| Ching W. Jaw | SVP Finance & CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.60 per share. | 02 Mar 2023 | 6,225 | 59,749 (0%) | 0% | 39.6 | 246,510 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.60 per share. | 02 Mar 2023 | 2,484 | 22,305 (0%) | 0% | 39.6 | 98,366 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.60 per share. | 02 Mar 2023 | 2,202 | 23,683 (0%) | 0% | 39.6 | 87,199 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 45.21 per share. | 21 Feb 2023 | 2,234 | 24,789 (0%) | 0% | 45.2 | 100,999 | Common Stock |
| Robert I. Blum | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.13 per share. | 16 Feb 2023 | 3,230 | 403,182 (0%) | 0% | 44.1 | 142,540 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.13 per share. | 16 Feb 2023 | 1,513 | 150,926 (0%) | 0% | 44.1 | 66,769 | Common Stock |
| Ching W. Jaw | SVP Finance & CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.13 per share. | 16 Feb 2023 | 1,210 | 65,974 (0%) | 0% | 44.1 | 53,397 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.13 per share. | 16 Feb 2023 | 510 | 27,023 (0%) | 0% | 44.1 | 22,506 | Common Stock |
| Andrew M. Callos | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 44.13 per share. | 16 Feb 2023 | 969 | 25,885 (0%) | 0% | 44.1 | 42,762 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Feb 2023 | 150 | 152,439 (0%) | 0% | 0 | Common Stock | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 43.74 per share. | 09 Feb 2023 | 7,000 | 156,589 (0%) | 0% | 43.7 | 306,180 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 43.73 per share. | 09 Feb 2023 | 4,000 | 152,589 (0%) | 0% | 43.7 | 174,920 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2023 | 7,000 | 81,322 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 09 Feb 2023 | 7,000 | 163,589 (0%) | 0% | 8.0 | 55,720 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.72 per share. | 06 Feb 2023 | 7,000 | 19,533 (0%) | 0% | 6.7 | 47,040 | Common Stock |
| Wendell D. Wierenga | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 7,000 | 6,020 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 06 Feb 2023 | 7,000 | 12,533 (0%) | 0% | 45 | 315,000 | Common Stock |
| Ching W. Jaw | SVP Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 15,000 | 3,056 | - | - | Incentive Stock Option (Right to Buy) | |
| Ching W. Jaw | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 03 Feb 2023 | 15,000 | 67,184 (0%) | 0% | 45 | 675,000 | Common Stock |
| Ching W. Jaw | SVP Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.10 per share. | 03 Feb 2023 | 15,000 | 82,184 (0%) | 0% | 12.1 | 181,500 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 03 Feb 2023 | 3,004 | 27,533 (0%) | 0% | 45 | 135,180 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 17 Jan 2023 | 10,000 | 416,412 (0%) | 0% | 9.7 | 96,500 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 10,000 | 145,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.43 per share. | 17 Jan 2023 | 10,000 | 406,412 (0%) | 0% | 42.4 | 424,300 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 40.47 per share. | 12 Jan 2023 | 4,000 | 156,589 (0%) | 0% | 40.5 | 161,880 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 44.24 per share. | 04 Jan 2023 | 10,000 | 406,412 (0%) | 0% | 44.2 | 442,400 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2023 | 10,000 | 155,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 04 Jan 2023 | 10,000 | 416,412 (0%) | 0% | 9.7 | 96,500 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 44.35 per share. | 03 Jan 2023 | 450 | 24,890 (0%) | 0% | 44.4 | 19,958 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 44.35 per share. | 03 Jan 2023 | 126 | 11,522 (0%) | 0% | 44.3 | 5,588 | Common Stock |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 44.35 per share. | 03 Jan 2023 | 253 | 12,533 (0%) | 0% | 44.4 | 11,221 | Common Stock |
| Sandford Drexel Smith | Director | Grant, award, or other acquisition of securities at price $ 44.35 per share. | 03 Jan 2023 | 253 | 12,533 (0%) | 0% | 44.4 | 11,221 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 44.35 per share. | 03 Jan 2023 | 253 | 13,049 (0%) | 0% | 44.4 | 11,221 | Common Stock |
| Robert A. Harrington | Director | Grant, award, or other acquisition of securities at price $ 44.35 per share. | 03 Jan 2023 | 253 | 5,253 (0%) | 0% | 44.4 | 11,221 | Common Stock |
| Robert I. Blum | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 3,035 | 406,412 (0%) | 0% | 0 | Common Stock | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2022 | 10,000 | 155,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.37 per share. | 21 Dec 2022 | 792 | 441,417 (0%) | 0% | 32.4 | 25,635 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 21 Dec 2022 | 792 | 442,209 (0%) | 0% | 8.0 | 6,304 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.37 per share. | 21 Dec 2022 | 11,708 | 441,417 (0%) | 0% | 32.4 | 378,954 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 43.92 per share. | 21 Dec 2022 | 10,000 | 406,412 (0%) | 0% | 43.9 | 439,240 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 21 Dec 2022 | 10,000 | 416,412 (0%) | 0% | 9.7 | 96,500 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 21 Dec 2022 | 11,708 | 453,125 (0%) | 0% | 9.6 | 112,982 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2022 | 792 | 10,000 | - | - | Incentive Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2022 | 11,708 | 0 | - | - | Incentive Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 36.28 per share. | 08 Dec 2022 | 4,000 | 160,589 (0%) | 0% | 36.3 | 145,120 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 39.30 per share. | 05 Dec 2022 | 10,000 | 406,412 (0%) | 0% | 39.3 | 392,970 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 10,000 | 165,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 05 Dec 2022 | 10,000 | 416,412 (0%) | 0% | 9.7 | 96,500 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 40.89 per share. | 21 Nov 2022 | 10,000 | 406,089 (0%) | 0% | 40.9 | 408,900 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Nov 2022 | 10,000 | 175,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 21 Nov 2022 | 10,000 | 416,089 (0%) | 0% | 9.7 | 96,500 | Common Stock |
| Robert C. Wong | VP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 40.68 per share. | 14 Nov 2022 | 2,100 | 30,537 (0%) | 0% | 40.7 | 85,428 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 38.04 per share. | 10 Nov 2022 | 4,000 | 164,346 (0%) | 0% | 38.0 | 152,160 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2022 | 792 | 185,691 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2022 | 9,208 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.17 per share. | 02 Nov 2022 | 792 | 406,089 (0%) | 0% | 42.2 | 33,399 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 02 Nov 2022 | 792 | 406,881 (0%) | 0% | 9.7 | 7,643 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.17 per share. | 02 Nov 2022 | 9,208 | 406,089 (0%) | 0% | 42.2 | 388,301 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 02 Nov 2022 | 9,208 | 415,297 (0%) | 0% | 8.0 | 73,296 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 19 Oct 2022 | 10,000 | 416,089 (0%) | 0% | 8.0 | 79,600 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Oct 2022 | 10,000 | 9,208 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 47.86 per share. | 19 Oct 2022 | 10,000 | 406,089 (0%) | 0% | 47.9 | 478,600 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 47.28 per share. | 13 Oct 2022 | 21,513 | 168,346 (0%) | 0% | 47.3 | 1,017,135 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2022 | 21,513 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 13 Oct 2022 | 21,513 | 189,859 (0%) | 0% | 9.6 | 207,600 | Common Stock |
| John T. Henderson | Director | Grant, award, or other acquisition of securities at price $ 51.11 per share. | 03 Oct 2022 | 391 | 24,440 (0%) | 0% | 51.1 | 19,984 | Common Stock |
| Nancy J. Wysenski | Director | Grant, award, or other acquisition of securities at price $ 51.11 per share. | 03 Oct 2022 | 110 | 11,396 (0%) | 0% | 51.1 | 5,622 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.40 per share. | 03 Oct 2022 | 10,000 | 406,089 (0%) | 0% | 50.4 | 504,000 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 03 Oct 2022 | 10,000 | 416,089 (0%) | 0% | 8.0 | 79,600 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Oct 2022 | 10,000 | 19,208 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Wendell D. Wierenga | Director | Grant, award, or other acquisition of securities at price $ 51.11 per share. | 03 Oct 2022 | 110 | 12,280 (0%) | 0% | 51.1 | 5,622 | Common Stock |
| Sandford Drexel Smith | Director | Grant, award, or other acquisition of securities at price $ 51.11 per share. | 03 Oct 2022 | 110 | 12,280 (0%) | 0% | 51.1 | 5,622 | Common Stock |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 51.11 per share. | 03 Oct 2022 | 220 | 12,796 (0%) | 0% | 51.1 | 11,244 | Common Stock |
| Muna Bhanji | Director | Grant, award, or other acquisition of securities at price $ 51.11 per share. | 03 Oct 2022 | 220 | 11,031 (0%) | 0% | 51.1 | 11,244 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.96 per share. | 19 Sep 2022 | 10,000 | 416,089 (0%) | 0% | 8.0 | 79,600 | Common Stock |
| Robert I. Blum | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Sep 2022 | 10,000 | 29,208 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 51.42 per share. | 19 Sep 2022 | 10,000 | 406,089 (0%) | 0% | 51.4 | 514,200 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.02 per share. | 12 Sep 2022 | 7,250 | 31,299 (0%) | 0% | 4.0 | 29,145 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2022 | 7,259 | 0 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2022 | 7,250 | 7,259 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2022 | 7,250 | 14,509 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 54.94 per share. | 12 Sep 2022 | 7,259 | 24,049 (0%) | 0% | 54.9 | 398,817 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.02 per share. | 12 Sep 2022 | 7,259 | 31,308 (0%) | 0% | 4.0 | 29,181 | Common Stock |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 54.95 per share. | 12 Sep 2022 | 7,250 | 24,049 (0%) | 0% | 55.0 | 398,402 | Common Stock |
| John T. Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.02 per share. | 12 Sep 2022 | 7,250 | 31,299 (0%) | 0% | 4.0 | 29,145 | Common Stock |
| John T. Henderson | Director | Sale of securities on an exchange or to another person at price $ 54.94 per share. | 12 Sep 2022 | 7,250 | 24,049 (0%) | 0% | 54.9 | 398,330 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.65 per share. | 08 Sep 2022 | 21,500 | 189,846 (0%) | 0% | 9.7 | 207,475 | Common Stock |
| Fady Ibraham Malik | EVP Research & Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 21,500 | 21,513 | - | - | Non-Qualified Stock Option (Right to Buy) | |
| Fady Ibraham Malik | EVP Research & Development | Sale of securities on an exchange or to another person at price $ 51.88 per share. | 08 Sep 2022 | 21,500 | 168,346 (0%) | 0% | 51.9 | 1,115,420 | Common Stock |
| Robert I. Blum | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 49.11 per share. | 07 Sep 2022 | 10,000 | 406,089 (0%) | 0% | 49.1 | 491,100 | Common Stock |